Low-dose Ketamine treatment is a breakthrough, effective, and accessible option for millions of people struggling with depression and anxiety.

We've treated over 50,000 patients with extraordinary results, including for patients with treatment-resistant depression.

How does ketamine work on the brain?

Ketamine is believed to affect neuroplasticity and mood regulation through its modulation of glutamate and its interactions with NMDA receptors. By blocking NMDA receptors, ketamine disrupts normal glutamate neurotransmission, supporting synaptic plasticity and contributing to the antidepressant effects found with ketamine treatment. Patients are able to make new neural connections and gain new perspectives over old triggers, beliefs, and experiences.

Ketamine is also believed to stimulate synaptogenesis by increasing BDNF (brain-derived neurotrophic factor) levels in certain brain regions. Depression and chronic stress can cause synaptic dysfunction by reducing the number of neuronal synapses in brain regions that regulate mood and cognition. Ketamine has been shown to promote the growth of new synapses, called synaptogenesis, contributing to the long-term antidepressant potential of ketamine treatment.

Ketamine Research Publications

"When you take ketamine, it triggers reactions in your cortex that enable brain connections to regrow"

"Ketamine could provide hope for people with serious depression"

"When you take ketamine, it triggers reactions in your cortex that enable brain connections to regrow"

Joyous Research

Joyous has successfully treated over 60,000 patients struggling with mental health conditions including depression, anxiety, and PTSD.

On average, over 89% of patients report improvements in anxiety after 1 month of treatment, and over 91% report improvements in depression after 1 month.

We monitor patients on a daily and weekly basis, ensuring patient safety and medication tolerance to optimize our patients' mental health outcomes.

To date, patients with severe depression and anxiety reach remission levels through standardized PHQ and GAD scores, in 8 weeks of treatment.

‍These results continue for the duration of treatment and many experience lasting improvements far beyond treatment.

Ketamine and
your brain

FAQs

TREATMENT

Is it compatible with other antidepressants?

Low-dose ketamine medication is compatible with other antidepressants. Many of our patients continue to take their antidepressants while on our treatment and have not had any issues. Your Joyous medical provider will review your medical history and current list of medications to ensure that Joyous is a good fit for you and there aren't any interactions.

How is it different from IV ketamine?

Our low dose ketamine protocol can be taken orally from the comfort of your home and does not require you to stop or pause your daily tasks. Low dose ketamine is considered a psycholytic dose, not a psychedelic dose. This means that our patients experience the positive benefits of improved mood, new perspective, and improved neural connectivity without the psychedelic experience.

Is there downtime?

Joyous uses a proprietary low dose ketamine protocol that is highly effective without the psychedelic experience. Our treatment uses a psycholytic dose that allows you to move beyond the superficial layers of your day-to-day mind, can help heal unhealthy neural pathways, and help you achieve the clarity you need to live the life you deserve. Our treatment requires no down time, special conditions, or "trip sitters," because our doses are low enough to not cause a psychedelic experience, and our providers monitor patient side effects and progress virtually. You can safely take our medication from the comfort of your home and continue to live your life.

How do I take the ketamine microdose?

Our ketamine medication comes in the form of "troches," small waxy squares that you place between your cheek and lip for about 15 minutes. Let the troche melt and once finished, you can spit the remaining wax out. Do not eat or drink while the troche is in to optimize absorption.

How does it compare to other Ketamine products?

Other ketamine treatments can range between $500-$3000/month for high doses of ketamine. Higher doses create more of a "psychedelic" experience which can be overwhelming for some patients and benefit from integration coaching after the experience. Joyous uses microdoses, small doses where our patients remain fully coherent and oriented, able to engage with therapy and therapeutic exercises from the comfort of their home. All for just $129/month, no monthly commitment, making us the most affordable at-home ketamine treatment option.

What happens if I stop treatment?

When you're ready to stop treatment, our team will create a plan to help you stop treatment safely. Withdrawal symptoms are rare in our clinical setting. As time passes and the ketamine is out of your system, the neuroplasticity benefits may begin to dull, but can be reactivated by starting treatment again.

How long do I need to take this treatment?

There is no set timeline, you can participate in our low-dose ketamine treatment long term if you feel it is benefitting you, or you can come off it at any time. Many of our patients have been on the Joyous treatment for years and still have mental health benefits, while others stop when they feel that is right for them. There have been no reported complications or problems with taking our ketamine treatment for extended periods of time when taken as prescribed. When/if you decide to come off of the medication, withdrawal symptoms are rare in a clinical setting, and we will provide you with our medical recommendations to ensure that you can stop treatment safely. The length of treatment is personal to every patient, and you have complete say over how long you take ketamine.

Joyous Patient Stories

Megann

Brandon G

My journey was great. I took it for 5 months. Now my anxiety is almost completely gone. Also my depression went away. I feel a whole lot better than I have in ten years

Jessica

Will

I have struggled with anxiety my whole life. Tried many unhealthy and prescribed remedies. None worked. Ketamine has been a game changer. I would highly recommend this to anyone...

Monika

It is so easy to let the little things go that I would normally obsess on. I used to start everyday just irritated at everything. Now my days are full of happiness and excitement.

Eva D

Quite literally life saving. Having been living with depression for 22 years, I never knew life could be this … well, joyous!! I feel like I have superpowers.

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